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Pathophysiology Crohns disease results from a dysregulated immune response to intestinal microbiota in genetically susceptible individuals, as described by StatPearls (NCBI)
The His-Phe-Arg-Trp tetrapeptide core (positions 69) is preserved intact and has been identified as the pharmacophore responsible for melanocortin receptor activation
J., Mohamed el, S
Burnand, Lausanne (Mdecine sociale et prventive)
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